A clinical observation of malignant pleural effusion treated by intrapleural perfusion with recombinant mutant human tumor necrosis factor

Objective:To approach the clinical effect and adverse reaction of recombinant metant human tumor necrossis factor(rmhTNF) and DDP in the treatment of malignant pleural effusion.Methods: Sixty patients with maligant pleural effusion were randomly devided into two groups:groupTNF was infused with rmhTNF,the another one was infused with DDP.The effective rate,responding time and adverse reaction were observed.Results: The total effective rate of rmhTNF group was 86.7%,while it was 66.7% in groupDDP.There was a significant difference between two groups(P0.05).Conclusion: The rmhTNF is more effective and responds qulickly with less adverse reaction for treatment of maliganat pleural effusion.