Abstract 19268: Robust Performance of LpPLA2 Activity in Predicting Cardiovascular Disease Risk in a National, Diverse, Sample

Introduction: LpPLA2 activity increases in inflamed plaques associated with atherosclerotic disease. Elevated circulating LpPLA2 is associated with increased risk of cardiovascular disease but it is not known whether this risk is consistent across demographic and risk groups. Methods: We developed a case cohort study within the REasons for Geographic and Racial Disparities in Stroke (REGARDS) study. We included a random cohort sample (n=3719) derived from the 23,019 REGARDS participants who were free from stroke and cardiovascular disease at baseline in 2003-7. We used weighted Cox models to study the association between LpPLA2 activity and risk of cardiovascular disease. Acute CHD during complete follow up through 12/31/2010 was adjudicated by an expert committee and defined as definite or probable myocardial infarction (MI) not resulting in death within 28 days (nonfatal acute CHD) or fatal acute CHD. LpPLA2 activity was measured using the PLAC® Activity Test at Diadexus. LpPLA2 activity was dichotomize...