Mathematical modeling of the dynamics of structural thyroid parameters in thyroid disease with immune disorders

The material of the study was surgical thyroid biopsies from 126 patients, males and females, aged 14-69 years. 5 groups were studied depending upon the histological picture and the degree of lymphoid infiltration. Thyroids from 10 persons without thyroid pathology who died a violant life served as control. As a result of the factor analysis 5 main factors were distinguished. The first one is lymphoid infiltration, the 2nd and 3rd ones-factors of thyroid epithelium characterizing the structure and the size of thyrocytes, the 4th and the 5th factors characterize the structure of the thyroid as an organ. The analysis confirmed lymphoid infiltration and thyrocyte dimensional parameters are the most important morphological criteria in the diagnosis of thyroid pathology with immune disturbances. Six equations are derived allowing to classify new cases of thyroid pathology.