Chemo-enzymatic process for the preparation of (S)-7-((tert-butyldiphenylsilyl)oxy)hept-1-yn-4-ol in a continuous packed-bed reactor (PBR), a key intermediate for eribulin synthesis.

A practical chemo-enzymatic process has been developed for the preparation of optically pure (S)-7-((tert-butyldiphenylsilyl)oxy)hept-1-yn-4-ol, (S)-4. This was prepared via enantioselective acylat...