Effect of individualized nursing intervention on the compliance of antiviral treatment among patients with chronic hepatitis C

Objective To improve the hepatitis C patients′ treatment compliance, and individualized interventions were conducted. Medical staffs and patients should work together to get longer and more sustained virological response. Methods A total of 78 patients with hepatitis C viral (HCV) who participated in the clinical trail of pegylated recombinant interferon varian (PEG-IFN-SA) were randomized into intervention group and control group during September 2011 to May 2012, 39 cases per group. At 4 weeks, 8 weeks and 12 weeks after treatment, 90 symptom checklist (SCL-90) questionnaires were tested among intervention group subjects, to know the problems about their society, family and metal health occurred throughout the treatment, then we coped with intervene targeted. The control group just visited according to protocol. Results In the intervention group, 29 (29/39, 74.36%) subjects completed the antiviral treatment, obviously higher than that of control group 19 (19/39, 48.7%) (χ2=5.41, P 0.05). In the study, there were 5 cases represented the symptom of anxiety and depression in the control group. Conclusions The individualized nursing intervention can effectively solve the patients′ response to the AEs of interferon anti-HCV for lack related knowledge, effectively relieve the negative emotion of patients caused by the adverse reactions, reduce the degree of mental abnormality occurs, increase the confidence of antiviral treatment, and greatly improve the HCV patients′ compliance, so as to improve the sustained response rate. Key words: Hepatitis, C type, chronic; Antiviral treatment; Compliance; Individualized nursing intervention