The role of microglia activation by pathological Tau protein in cognitive impairment

Neurofibrillary tangle (NFT) formed by hyperphosphorylated Tau is considered to be one of the important reasons of cognitive impairment. Hyperphosphorylated Tau exists in many forms in the central nervous system, producing toxic effects on neurons and activating microglia to induce immune response. This paper aims to explore the neurotoxicity of pathological Tau and to elucidate the role of microglia in its association with cognitive impairment. By regulating the differentiation direction of microglia and controlling the secretory factors of differentiated microglia, we can intervene in the cognitive impairment caused by pathological Tau protein. Key words: Tau; Microglia; Neurodegenerative disease; Cognitive impairment