Caveolin-1 in cell migration and metastasis.
2014
Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early
stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages,
caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms
associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role
of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and
metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as
well as mechanisms by which this may be achieved.
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