The effect of nicotinamide and nicotinic and ascorbic acids on the penicillin concentration in the blood serum and tissues of rabbits

: Measurements of penicillin concentrations in the blood sera and tissues of rabbits have revealed a reduction of this antibiotic levels as the doses of injected ascorbic acid grew. A combination of benzylpenicillin with ascorbic and nicotinic acids improved penicillin penetration into experimental animals' tissues.