Rh-Catalyzed Syntheses of Chiral Monohydrosilanes via Intramolecular C-H Functionalization of Dihydrosilanes.

The preparation of chiral monohydrosilanes remains a rarely achieved goal. To this end we developed a Rh catalyzed desymmetrization of dihydrosilanes by way of intramolecular C(sp2)-H functionalization under simple and mild conditions. This method provides easy access to a broad range of chiral monohydrosilanes in good yields with excellent enantioselectivities (up to >99% ee). The monohydrosilanes constitute a good platform to access stereogenic silicons, as well as useful tool compounds to probe silicon stereochemistry.