LOTUS, a potent blocker of Nogo receptor-1 causing inhibition of axonal growth

Glia-derived axonal growth inhibitory proteins limit functional repair following damage to the adult central nervous system(CNS).Nogo proteins,myelin-associated glycoprotein(MAG),oligodendrocyte myelin glycoprotein(OMgp)and B lymphocyte stimulator(BLy S),are 4 inhibitors that commonly interact with the neuronal receptor,Nogo receptor-1(Ng R1),leading to inhibition of axonal growth.Here,we demonstrate that lateral olfactory tract usher substance