Tebipenem pivoxil preparation and preparation method thereof

The invention discloses a tebipenem pivoxil preparation and a preparation method thereof. The tebipenem pivoxil preparation is prepared from granules, a first coating layer and a second coating layer, the granules are composed of tebipenem pivoxil, D-mannitol, microcrystalline cellulose, sucrose and hydroxypropylcellulose, the first coating layer is composed of ethyl cellulose suspension, talcum powder, hydroxypropylcellulose and purified water, and the second coating layer is composed of ethyl acrylate-methyl methacrylate copolymer aqueous dispersion, talcum powder, hydroxypropylcellulose, aspartame and purified water. The granules are coated twice, and ethyl cellulose is nontoxic and pharmacological activity, thereby being an ideal insoluble material; the ethyl acrylate-methyl methacrylate copolymer aqueous dispersion is used as a gastric-soluble thin film coating material of granules, and a film formed by the material can resist saliva, so that during taking, uncomfortable taste of the tebipenem pivoxil preparation can be covered. The tebipenem pivoxil preparation is insoluble in water and digestive liquid but can expand and has permeability.