ON THE EFFECT OF GLUCURONIC ACID UPON STOMACH ULCER IN EXPERIMENTAL DIPHTHERIA

Investigations were carried out on the relation of adrenal cortical hormone to stomach ulcer produced by the injection of diphtheric toxin, and on the effect of glucuronic acid on this ulccr.1) Stomach ulcer by diphthcric toxin was made severer by the administration of hydrocortisone, and remarkably improved by the administration of glucuronic acid preparation. 2) It is considered that this ulcer has much of the features of stress-ulcer, and that the inhibition by glucuronic acid is due to the binding of adrenal cortical hormone by this acid.