Lipidosome-polymer particle preparation of topical anaesthetic and preparation method of lipidosome-polymer particle preparation

The invention relates to the field of pharmaceutic preparations, in particular to a lipidosome-polymer particle preparation of topical anaesthetic and a preparation method of the lipidosome-polymer particle preparation. The lipidosome-polymer particle preparation of the topical anaesthetic is prepared from, by mass, 150-250 parts of topical anaesthetic, 300-350 parts of PLGA, 100-150 parts of stabilizer, 400-430 parts of phospholipid and 100-105 parts of cholesterol. The preparation is small in grain size, stable in property and good in release effect. The average grain size of the preparation is 40.15 micrometers, and the encapsulation rate is 81.8%. After dissolution rate inspection is carried out for 72 hours in a buffer salt medium with the pH of 7.4, the dissolution rate exceeds 80%. Besides, the preparation is placed for 10 days at the temperature of 30 DEG C, and the permeability does not exceed 15% and is superior to that in the prior art. In addition, the preparation method of the preparation is simple, the requirement for production equipment is not high, and the production period is short.