Process for preparing cilexetil cardesartan in crystalline form.
2006
Process for the preparation of candesartan cilexetil in crystalline form. a process for preparing a crystalline form of candesartan cilexetil denominated Form I having a content named form II below 1% by weight is described. Said method comprises a step of seeding with a crystalline product comprising a major proportion of form I, and digestion step. The invention also relates to said crystalline form, pharmaceutical compositions containing them and their use for the preparation of a medicament for the treatment of hypertension. It has been observed that the candesartan cilexetil Form I has good stability when kept at accelerated stability conditions if a content of the lower form II at 1% by weight.
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