Abstract WP200: Development and Validation of a Score to Detect Paroxysmal Atrial Fibrillation During Long-term Holter-monitoring After Acute Ischemic Stroke

Introduction: Atrial fibrillation remains one of the most common causes of ischemic stroke. The diagnosis of paroxysmal atrial fibrillation (pAF) frequently escapes routine diagnostic due to its intermittent and asymptomatic occurrence. Currently prolonged monitoring times (72h) are recommended, but did not find their way into everyday practice. Therefore an individual patient selection for prolonged ECG-monitoring might increase the diagnostic yield of pAF in a resource-saving and cost-effective manner. Methods: We used individual patient data from three prospective studies (ntotal=1556) which performed a prolonged Holter ECG-monitoring (at least 72 h) and centralized data evaluation after ischemic stroke (IDEAS 72h monitoring, Find-AF 7 days and Find-AFrandomised3 times 10 daysmonitoring) in patients presenting with sinus rhythm. The score was developed on the IDEAS cohort and internally (bootstrapping) and externally (Find-AF and Find-AFrandomiseddata) validated following the TRIPOD guideline. Results:...