The Toxicology of Perfluorodecanoic Acid in Rodents

Abstract : Perfluoro-n-decanoic acid or nonadecafluoro-n-decanoic acid (NDFDA) is a straight chain, perfluorinated, ten-carbon acid. Experiments were conducted to determine the LD50 and to evaluate survival times of rats after single intraperitoneal (IP) injections of NDFDA or of Fluorooctanoic acid (PFOA), the shorter-chain analog, dissolved in propylene glycol/water (1:1, v:v). Ten male Fischer 344 rats were used in each dose group and an additional 10 rats were used in each dose group and an additional 10 rats were given 2 mL/kg propylene glycol/water, the same dosing volume used with all experimental animals. With NDFDA, the LD50/14 days was 63.6 mg/kg, and the LD50/30 days was 41.4 mg/kg. With PFOA, there was no mortality after the 5th day following injection, and both the LD50/14 and LD50/30 were 188.7 mg/kg.