Isolation and properties of gene-modified mouse bcr-abl-transformed cells expressing various immunostimulatory factors

mHC class I molecules. From populations of each of the three lines several cell clones were isolated and tested for the production of the respective cytokines. The original uncloned population and several clones differing in the cytokine production were administered intravenously into mice. all animals survived without symptoms of the disease suggesting that the gene-modi - fication was associated with the loss of pathogenicity.