Peroneus Brevis Muscle Flap with the use of INTEGRA® Wound Matrix and Split Thickness Skin Graft in the Treatment of Full Thickness Ulcerations: Case Reports and Technique Guide

2015 
One major factor contributing to chronic non-healing ulcerations is the lack of an adequate wound base in which proliferation of the wound can occur. Furthermore, disruption of the soft tissue envelope, either by surgical or non-surgical means, can leave little to no foundation to cover vital underlying structures. For example, post surgical wound dehiscence following open reduction and internal fixation can result in exposed hardware and without viable soft-tissue to cover the exposed hardware, an adequate wound base is incapable of forming. Therefore wound proliferation will not continue.
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