Distribution of Cefbuperazone in the oral tissue of mice

Cefpiramide distribution in oral tissue and inflamed mouth floor of mice was examined by agar well method.After abdominal administration of Cefpriramide 200μg/g to the mice, the tissue concentration of serum reached d peak in 5 minutes, that of the mandibular bone, tongue, masseter, mouth floor, submandibular gland, and femur in 10 minutes. The tissues in order of concentration were the serum, mouth floor, tongue, submandibular gland, mandibular bone, masseter and femur.After abdominal administration of Cefpiramide 200μg/g to the mice whose mouth floor had been inflamed, the concentration of the inflamed mouth floor reached a peak in 10 minutes. Compared with the normal mouth floor, Cefpiramide was distributed in a low position in inflamed mouth floor, but it seems likely that the maintenance of the concentration is good because of the high distribution in 60 minutes after the administration.