Incorporation of a triglutamyl spacer improves the biodistribution of synthetic affibody molecules radiofluorinated at the N-terminus via oxime formation with (18)F-4-fluorobenzaldehyde.

Daniel Rosik,Alf Thibblin,Gunnar Antoni,Hadis Honarvar,Joanna Strand,Ram Kumar Selvaraju,Mohamed Altai,Anna Orlova,Amelie Eriksson Karlström,Vladimir Tolmachev

Incorporation of a triglutamyl spacer improves the biodistribution of synthetic affibody molecules radiofluorinated at the N-terminus via oxime formation with (18)F-4-fluorobenzaldehyde.

2014

Daniel Rosik
Alf Thibblin
Gunnar Antoni
Hadis Honarvar
Joanna Strand
Ram Kumar Selvaraju
Mohamed Altai
Anna Orlova
Amelie Eriksson Karlström
Vladimir Tolmachev

Affibody molecules are a class of affinity agents for molecular imaging based on a non-immunoglobulin protein scaffold. Previous studies have demonstrated high contrast for in vivo imaging of cance ...

Keywords:

Combinatorial chemistry
Scaffold protein
Molecule
Preclinical imaging
4-fluorobenzaldehyde
Stereochemistry
Molecular imaging
Oxime
N-terminus
Biodistribution
Chemistry

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