Synthesis and biological evaluation of fatty acids containing 99mTc-oxo and 99mTc-nitrido for myocardial metabolism imaging

In this study, four 99mTc-labeled fatty acid analogues including [99mTcO]3+ and [99mTc≡N]2+ cores were successfully synthesized and fully characterized. The radiochemical purity of those compounds was over 90 % and they were stable when incubated in a rat serum for 3 h at 37 °C. The biodistribution studies in mice demonstrated that compounds labeled with [99mTcO]3+ exhibited good uptakes (6.11 %ID/g of [99mTcO]-MAMA-DTA and 3.89 %ID/g of [99mTcO]-MAMA-UTA at 1 min postinjection) and the maximum heart to blood ratio was 5.91 at 30 min postinjection of [99mTcO]-MAMA-DTA. While the others labeled with [99mTc≡N]2+ showed lower uptakes and faster washout from the myocardium.