The study of USP22 activation in colorectal cancer

Objective To investigate the expression of USP22 in colorectal carcinoma. Methods 192 cases of colorectal carcinoma were examined by immunohistochemical staining. Results USP22 expression significantly increased from normal mucosa and adenoma to primary carcinoma(P<0.0001). And increased from primary carcinoma to liver metastasis(P=0.021)as well.Expression of USP22 was highly correlated with gender, tumor size, pT, pN, and Ki-67 expression(P<0.05). Conclusion USP22 protein could be useful in evaluating the malignancy of colorectal cancer. Key words: Colorectal neoplasms; Metastasis; USP22