One-Pot Synthesis of Functionalized Piperid-4-ones: A Four-Component Condensation.
2008
The one-pot synthesis of highly substituted piperid-4-ones has been achieved. Diketene is added to a tosyl imine in the presence of TiCl4 and MeOH, followed by 1 equiv of aldehyde to generate 2,6-disubstituted nonsymmetrical piperid-4-ones as a mixture of cis-/trans-diastereomers in good yields. This mixture of diastereomers can be converted to a single 2,6-cis-diastereomer by epimerization with K2CO3.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
0
Citations
NaN
KQI