Multiple Sclerosis Pain

Chronic pain that is associated with multiple sclerosis (MS) can be a challenging entity to the treating clinician. A number of chronic pain conditions affecting patients with MS have been described, including headache, musculoskeletal pain, low back pain, and neuropathic pain. This prevalent condition within the population with MS requires an appropriate evaluative approach, including a thorough history, a targeted physical examination, and appropriate use of radiologic imaging and diagnostic testing. A multitude of management approaches exist, including nonpharmacologic, rehabilitative, pharmacologic, and interventional approaches. The chapter provides an overview of the epidemiology, classification, evaluation, and management of MS-associated pain.