Analogues of arginine vasopressin (AVP) modified in the N-terminal part of the molecule with N-benzylglycine

The synthesis and some pharmacological properties of five new analogues of arginine vasopressin (AVP) substituted with N-benzylglycine are described. All new peptides were tested for pressor and uterotonic activity. The results obtained imply that the structural change studied is in general incompatible with interaction of the analogues with VIA and OT receptors, however, in combination with suitable additional changes, may be of value in the design of new antagonists of these receptors.