An efficient one pot three-component domino reaction for the synthesis of 1,3,4-trisubstituted pyrroles

An efficient synthesis of 1,3,4-trisubstituted pyrroles via three-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones, anilines and β-nitrostyrenes in acetic acid is described. This one pot three-component transformation presumably proceeds via addition–elimination/Michael addition/intramolecular annulation/elimination domino sequence of reactions with one C-C and two C-N bonds formation in a single synthetic operation. Additionally, this methodology has been applied to the formal synthesis of an antifungal agent as well.