The antitumor agent according to the combination of a compound having a kinase-inhibitory effect

Anti-tumor agents used in combination acceptable salt wherein the compound represented by the general formula (I) or a compound represented by the pharmaceutically acceptable salts and formula (II) or a pharmacologically may each compound compared to when used alone, it showed significant anti-tumor effect and shows an antitumor effect against a variety of cancer types. [In the formula, ]