Immunological dysfunction and MCI-like behavior in the 3xTgAD mice

were found in 5xFAD versus non-Tg mice. Conclusions: Preliminary results suggest there is immune cell activation and neuroinflammation in the 5xFAD by 4 months of age leading to increased levels of immune cells at 6 months of age. Studies are now in progress to determine the source (central versus peripheral) of immune cell activation and extent to which chronic systemic inflammation promotes peripheral immune cell traffic to the CNS.