Comparison of automated ACMIA and EMIT immunoassays for whole blood cyclosporin monitoring

OBJECTIVE: Evaluation of a new fully automated antibody conjugated magnetic immunoassay (ACMIA) for whole blood cyclosporin (CsA) monitoring. METHOD: Evaluation of the analytical performance of the ACMIA method and comparison to the Enzyme Multiplied Immunoassay (EMIT) method. RESULTS: The analytical performance of the ACMIA and the EMIT methods was comparable. Without the need of a pretreatment step of the sample, the ACMIA method is faster than the EMIT method. CONCLUSION: The ACMIA method for CsA monitoring is a good alternative to the EMIT method.