Combined optical coherence tomography and broadband single fiber reflectance spectroscopy

We present a bi-modal bench-top system combining OCT with broadband, single-fiber reflectance spectroscopy. This combination aims to address the limited molecular sensitivity of standard OCT imaging in order to obtain co-registered morphological and molecular information. We present various technical innovations for this work, including an all-reflective scanner head with adaptive optic components for focus scanning and reduction of field curvature. Furthermore, we demonstrate the use of specialty fiber components to obtain multiple illumination schemes for the spectroscopic channel and enhance the spatially resolved reconstruction of optical properties.