Nefrite intersticial aguda após exposição a Losartan

Nefrite intersticial aguda e uma causa comum de perda aguda de funcao renal. Exposicao a drogas e o fator desencadeante mais frequentemente relatado, porem auto-imunidade e infeccoes tambem estao associadas. Os inibidores da enzima de conversao da angiotensina tem sido relatados como possiveis agentes, porem nao ha relato na literatura de nefrite intersticial com uso de losartan. Descrevemos o caso de perda aguda de funcao renal apos exposicao a losartan, em paciente com dano renal previo por nefropatia diabetica, cuja biopsia renal diagnosticou nefrite intersticial aguda Acute interstitial nephritis is an important cause of acute renal failure. The majority of cases results from exposure to drugs. However imune-mediated injury and infection are common causes. The angiotensin-converting enzyme inhibitors have been implicated as possible etiologic agents, but we could not find previous data of acute intestitial nephritis associated with losartan exposure. We report a case of acute renal failure after losartan exposure, in a patient with diabetic nephropathy. The final diagnosis was confirmed by renal biopsy: acute interstitial nephritis