The phenotype of the Adult Mexican Patient with Pulmonary Arterial Hypertension: Baseline characteristics of the REMEHIP Registry. The REMEHIP Investigators.

The Mexican Registry of Pulmonary Hypertension (REMEHIP) was launched in December 2015 to provide updated characteristics in Mexican pediatric and adult patients with PH of groups I and IV of the updated WHO clinical classification. We report on the baseline characteristics of adult patients with pulmonary arterial hypertension (PAH). Methods: REMEHIP is an ongoing multicenter registry, collecting data from prevalent and incident PH cases confirmed by right heart catheterization. Twenty-three centers enrolled consecutive patients with pulmonary hypertension who met hemodynamic criteria of PAH: mean pulmonary artery pressure >25 mm Hg at rest, pulmonary capillary wedge pressure 240 dynes•s•cm-5. Results: Between Dec. 2015 and Oct. 2017, 796 patients were enrolled. Among 550 adult patients meeting traditional hemodynamic PAH criteria, the mean age was 42 ± 17 years, and 455 (82.5%) were women. Forty-seven percent of cases were incident, and 53% were prevalent. Etiologies: idiopathic PAH (43%), PAH-CHD (37.5%), PAH-CTD (15.8%) and other (3.8%). Seventy-two percent of the patients were in functional WHO class I and II at inclusion and the six-min walk distance was 382 ± 113 m. The median duration between symptom onset and diagnostic catheterization was 16 (6-36) months and 88% patients were treated with PAH-targeted therapies. Conclusions: Patients in the REMEHIP Registry are younger, more often female, and are in a better functional class than those in recent US and European registries. Differences in phenotype might be explained by a different ancestry.