High Dose Pralidoxime (PRX) Treatment Prolongs Time to Extubation (TTE) and Increases Mortality in Paraoxon (POX) Exposed Minipigs: [2002][A-336]

Abstract : Organophosphates are inhibitors of serine hydrolases. Oximes are clinically available enzyme reactivators. To determine in vivo the effect of high dose PRX use on "time-to-extubation (TTE)" and mortality as compared to identical therapy without PRX. 12 anaesthetized minipigs were used. All pigs received iv-POX (lmg/kg BW) over 50 minutes. Group one (n = 6) received conventional intensive care therapy as described previously J Appi Toxicol 18: 293 - 298. Group two (n = 6) received in addition iv-PRX 10 g ( 300 mg/kg BW). Before BASE-LINE;BL, after POX application (50 min) and then at 1,2,3,4,8 and 16 hours after POX AChE and BChE activities were measured. Statistics: rank order test; significance for p Pralidoxime therapy has no beneficial effect and its use can not be recommended.