Extended release of adenovirus from silica implants in vitro and in vivo

L Kangasniemi, M Koskinen, M Jokinen, M Toriseva, R Ala-Aho, V-M Kahari, H Jalonen, S Yla-Herttuala, H Moilanen, U-H Stenman, I Diaconu, A Kanerva, S Pesonen, T Hakkarainen and A Hemminki Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory, University of Helsinki, Helsinki, Finland; HUSLAB, Helsinki University Central Hospital, Helsinki, Finland; DelsiTech Ltd, Turku, Finland; Turku Center for Biomaterials, University of Turku, Finland; Department of Dermatology, University of Turku, Turku, Finland; Department of Medical Biochemistry and Molecular Biology, University of Turku, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland; AI Virtanen Institute, Kuopio, Finland; Department of Medicine, University of Kuopio, Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland; HUS Pharmacy, Helsinki, Finland; Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland and Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland