Model of evaluation of the dynamics of left ventricular diastolic function in acute decompensated heart failure. Effect of ivabradin

Aim — to reveal the connection between the initial morphofunctional characteristics of patients and the dynamics of changes in the diastolic function at the time of, as well as during 6 months of observation after the episode of acute decompensated heart failure against the background of standard therapy and with adding the If-channel blocker ivabradine. Material and methods . We examined 127 patients hospitalized with the episode of the acute decompensated heart failure with a sinus rhythm and heart rate more than 85 beats per minute. Among them 67 patients received ivabradine in addition to standard therapy, 60 patients were in control group. A 6-minute walk test, echocardiography assessment of systolic and diastolic function, electrocardiography (heart rate and rhythm) were performed on the day of admission (except for the 6-minute walk test), in 1 and 6 months later. Results . A scoring of the chance for positive dynamics of diastolic function was obtained in patients with acute decompensated heart failure, in the presence of certain initial characteristics of patients, such as: systolic pulmonary artery pressure 50% ( p 0,46 ( p < 0.005), female. A relationship between improvement in diastolic function and improvement in results of 6-minute walk test was found: with a positive dynamics of diastolic function, patients began to walk a distance in the 6-minute walk test by 6,9 ± 2,9 meters more ( p < 0.0005). Conclusion . The data obtained in our study confirm the advisability of adding ivabradine to the standard therapy of patients with acute decompensated heart failure with the determined “useful” morphofunctional characteristics.