Electroanalytical Determination of Acetaminophen Using a Polymerised Carbon Nanotube Based Sensor

In this paper, acetaminophen (AP), typically consumed as a painkiller, was sensitively detected using an electrochemical sensor through cyclic voltammetry. Therefore, special attention focused on fabricating a sensitive voltammetric sensor based on cetrimide (CA) incorporated on a poly oxalic acid modified carbon nanotube paste electrode (POAMCNTPE). The topographical features and electrochemical characterisations of unmodified and modified electrodes were compared using a variable pressure scanning electron microscope (VP-SEM) and electrochemical impedance spectroscopy (EIS). The scan rate study reveals that the redox reaction of the AP at the surface of the modified electrode was controlled by diffusion. The detection limit (DL) of 1.50 × 10−8 M and quantification limit (QL) of 5.02 × 10−8 M was gained by utilising differential pulse voltammetry (DPV). The constructed electrochemical sensor displayed acceptable repeatability, excellent stability, and adequate reproducibility. The prepared sensor exhibited an outstanding selectivity to detect the AP in the presence of dopamine (DA) and folic acid (FA). The practicability of the proposed electrode was examined to be successful towards the quantification of AP in both pharmaceutical and biological samples.