Effects of Shengmai injection on congestive heart failure patients with abnormal flow-mediated dilation of brachial artery volume

AIMTo observe the effect of Shengmai injection on congestive heart failure(CHF) patients with abnormal flow-mediated dilation(FMD) of brachial artery volume. METHODS:60 patients were randomly divided into two groups:the routine treatemtn group(n=28), who were given anti-failure therapy and the Shengmai injection treatment group (n=32),who were treated by combination of routine therapy and Shengmai injection which was given by intravenous infusion of 20~40 ml,once a day for 14 days. Brachial artery blood vessel ultrasonic examination and movement tolerance test were performed before and after the therapy. The routine therapy group(n=20) were not given any treatment. RESULTS:① It was found that the total clinical effective rate of the Shengmai injection group was significantly higher than that of the routine treatment group. The time for heart failure correction was greatly shortened and the time for movement loerance was also significantly prolonged in the Shengmai injection group.compared with the routine treatment group. ②the activity of FMD of brachial artery of the CHF patients was significantly weakend compared with that of the control group(P0.01). ③The activity of FMD of brachial artery was significantly strengthened after Shengmai injection therapy,which was remarkably different from that of the routine treatment group(P0.01). CONCLUSION:As shengmai injection therapy the obvious dependent dilate function disorders CHF patients suffer could correct by strengthening the FMD activity of brachial artery. shengmai injection is an efficacious drug for treating CHF patients.