Reply: Not-So-Random Errors: Randomized Controlled Trials Are Not the Only Evidence of the Value of PET

1822 Objectives To evaluate extra-aortic arterial FDG accumulation in asymptomatic cohorts by sex, and to clarify the association with cardiovascular risk factors (CRF) and coronary artery stenosis (CAS). Methods A total of 529 individuals who underwent a cancer and CAS screening using FDG-PET/CT and coronary MRA were enrolled.The subjects consisted of 358 men and 171 women (mean:57, range:28-84 yrs).We visually evaluated extra-aortic accumulation in carotid artery (CA) and iliac to femoral artery (IFA), and accumulation pattern was classified to 3 types.Type1 subjects had no extra-aortic accumulation, type2 had accumulation in either CA or IFA, and type3 had accumulation in both CA and IFA. CRF [age, LDL, HDL, and TG concentration, visceral abdominal fat (VAT), HT, diabetes, smoking] and severe CAS (75%≦) of proximal to mid-portion were examined in relation to each accumulation type. Results Men showed broader extra-aortic arterial accumulation than women. Type3 accumulation (60.3 vs. 36.8%, p Conclusions Extra-aortic arterial FDG accumulation correlated with CRF.Type3 accumulation was more common in men, and this accumulation was associated with age and/or VAT. Type 3 accumulation was considered to be a risk for severe CAS