Análisis coste-efectividad de enoxaparina en la profilaxis de la enfermedad tromboembólica venosa en pacientes sometidos a cirugía mayor ortopédica

Summary orthopedic surgery from the standpoint of the Spanish national health system. Episodes avoided and life-years gained with each treatment were estimated by a meta-analysis of clinical trials. Results: With enoxaparin fewer thromboembolic episodes and deaths occurred, when compared to the available alternative options. Enoxaparin was the dominant option (lower total cost and equal or greater effectiveness than any alternative option) in compa- rison with non-prophylaxis, tinzaparin, and unfractionated heparin. A sensitivity analysis confirmed the stability of these results. Conclusion: The administration of enoxaparin as a prophylac- tic treatment for venous thromboembolic disease in patients under- going hip or knee surgery is a cost-effective intervention in every case, and less expensive than the alternative options used in Spain.