Molecular genetics of cystic fibrosis.

The gene for cystic fibrosis (CF) has recently been isolated (Rommens et al., 1989a; Riordan et al., 1989; Kerem et al., 1989) rendering it possible for the first time to study the elusive symptoms of the disease. In this brief review, we try to summarize our current understanding of the CF gene and our attempts to study the gene product and its function. We have also included a short discussion on the correlation between genotype and phenotype in CF patients.