Protective Effect of Curcuma Against Chromium Hepatotoxicity in Rats

This study was carried out to investigate the antioxidant effects of curcuma against chromium-induced alterations in hepatic indices and dysfunctions in the antioxidant system. Forty male Wistar rats were randomly divided into four groups and were treated for 30 consecutive days. The control group (0-0) received per os mineral water and normal diet. The second group (0-Cur) received mineral water and an experimental diet containing 2% of curcuma powder, whereas the third group (Cr-0) was orally fed (per os) with 15 mg/kg body weight/day of potassium dichromate and normal diet. The last group (Cr-Cur) received per os 15 mg/kg of potassium dichromate and a diet with 2% of curcuma. The treatment by chromium was found to elicit a perturbation in biochemical parameters producing a significant increase in glycemia, triglycerides, cholesterol, ALP, ALT, AST, and LDH levels. On the contrary, a significant reduction was observed in the oxidative stress-related parameters (GSH, GPx, CAT, and GST). Moreover, we noticed that liver sections of rats intoxicated with chromium showed a disrupted architecture. However, the administration of curcuma revealed an intense reduction in the oxidative stress induced by chromium, ameliorating the levels of the majority of the previous parameters. The data of this study revealed the potent antioxidant effects of curcuma in reducing oxidative stress damage induced by the hexavalent chromium.