HspB8 expression in brain tissue after cerebral ischemic reperfusion and atorvastatin intervention in Sprague-Dawley rats.

AbstractObjective:The aim of this study was to evaluate the expression of HspB8 in the brain cortex of Sprague–Dawley rats after cerebral ischemic reperfusion (I/R) and atorvastatin intervention. It also aimed to determine the possible mechanism of atorvastatin intervention. A model of cerebral I/R in Sprague–Dawley rats was used.Methods:Fifty-two male Sprague–Dawley rats were randomly divided into four groups. The normal and sham-operated groups received no treatment. The I/R group was intragastrically administered with physiological saline, and the intervention group received atorvastatin (10 mg/kg) prepared with physiological saline according to reperfusion time (time of palinesthesia, 24 and 48 hours). All rats were killed after 72 hours of reperfusion.Results:2,3,5-Triphenyltetrazolium chloride staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling showed that atorvastatin significantly reduced the volume of cerebral infarction (%) in the brain tissue and attenuated neuron...