Angiogenic markers predict kidney injury and obstetric complications in women with preeclampsia and Pregnancy related Acute Kidney Injury.

Pregnancy related acute kidney injury (PRAKI) particularly on top of preeclampsia (PE) represents a major cause of maternal and fetal morbidity and mortality. Reliable diagnostic tools are needed to further evaluate diagnosis and prognosis of PRAKI. Our objective was to Study the diagnostic and prognostic value of angiogenic markers (e.g., Stromal cell-derived factor 1 (SDF-1), Vascular Endothelial Growth Factor (VEGF), Alarmins as uric acid) in women with preeclampsia and PRAKI. This prospective study included three groups; PRAKI, Preeclampsia patients and healthy controls that were compared regarding serum levels of the studied markers; correlated to renal, maternal and fetal outcomes. SDF-1, VEGF and uric acid levels were significantly different between the three included groups and predicted PRAKI diagnosis. Patients with Hemolysis, Elevated Liver enzymes, Low Platelet (HELLP) syndrome exhibited the highest titers of SDF-1 and VEGF. A positive correlation was found between SDF-1 and renal recovery. Conclusively, serum assays of SDF-1, VEGF and uric acid may add a diagnostic value in PRAKI and PE.