T-cell large granular lymphocyte leukemia transfomation into aggressive T-cell lymphoma: a report of two cases with molecular characterization

T-cell large granular lymphocyte (LGL) leukemia, a clonal expansion of cytotoxic CD3+ T cells, represents 5% of lymphoproliferative disorders. Clinical features include neutropenia causing recurrent bacterial infections, anemia of diverse mechanisms, and autoimmune diseases such as rheumatoid