Cofactor engineering through heterologous expression of an NADH oxidase and its impact on metabolic flux redistribution in Klebsiella pneumoniae

Xiao-Jun Ji,Zhifang Xia,Ninghua Fu,Zhi-Kui Nie,Meng-Qiu Shen,Qian-Qian Tian,He-ping Huang

Cofactor engineering through heterologous expression of an NADH oxidase and its impact on metabolic flux redistribution in Klebsiella pneumoniae

2013

Xiao-Jun Ji
Zhifang Xia
Ninghua Fu
Zhi-Kui Nie
Meng-Qiu Shen
Qian-Qian Tian
He-ping Huang

Background Acetoin is an important bio-based platform chemical. However, it is usually existed as a minor byproduct of 2,3-butanediol fermentation in bacteria.

Keywords:

Klebsiella pneumoniae
Biochemistry
Acetoin
Cofactor Engineering
Biotechnology
Heterologous expression
NADH oxidase
Biology
Fermentation
Microbiology
2,3-Butanediol
Bacteria
NAD+ kinase
Cofactor
Metabolic flux analysis
Lactic acid

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