Anti-inflammatory activities of phytochemicals from Bauhinia variegata Linn. leaf: An in silico approach

Inflammation is part of the complex biological resp onse of vascular tissues to harmful stimuli, such a s pathogens, damaged cells, or irritants. Cyclooxygenase-2 (COX- 2) and inducible Nitric Oxide Synthase (iNOS) plays an important role in inflammation and thus they act as a promising molecular target for the treatment of many inflammatory diseases. Present study was aimed to f ind out COX-2 and iNOS inhibiting compounds from Ba uhinia variegataLinn. 3D structures of compounds reported from GCMS analysis of active fractions of B.variega ta were built using Chemsketch software. All the compounds analyzed exhibited antiviral, antibacterial, antine oplastic, antidiabetic and anti-inflammatory properties. Dock ing studies were performed using Glide (Grid-based Ligand Docking with Energetics) Extra Precision (XP) 5.7 a lgorithm in Schrodinger Software Suite, 2011 analys is. Drug likeliness (ADME) property using Lipinski RO5 was apredicted. Among the 33 ligands of the active f ractions,