Residual disease after neoadjuvant chemotherapy for breast cancer.

2010 
Locally advanced breast cancer is a clinical quandary for which there is no standard treatment regimen. Often, preoperative chemotherapy regimens are chosen from proven regimens recommended for the adjuvant setting, as accepted by national panels. There are several accepted characteristics of breast tumors that may predict greater response to neoadjuvant chemotherapy, including phenotype, nuclear grade, and proliferation index. The following cases illustrate two clinical situations in which the neoadjuvant chemotherapy given yielded partial to near complete responses, yet left questions for the clinician regarding the optimum approach to best reduce the risk of recurrence.
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