Activation of cannabinoid receptors reduces allergen-induced oxidative stress damage during asthma-like reaction in sensitised guinea-pigs

A large number of studies indicate that increased levels of oxygen-derived free radicals produced by infl ammatory and epithelial cells in the airway are important mediators in the pathogenesis of asthma [1, 2]. Cannabinoids, reported to have antioxidant properties [3], are known to induce their bi-ological effects by binding to specifi c cannabinoid receptors, designated CB