Thienyl-, Furyl-, Pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

The present invention provides thienyl - conditioning and sulfonamide or alter the activity of the peptide-based endothelin - and pyrrolyl -, furanyl. Specifically, to provide N- (isoxazolyl) thiophene-sulfonamide, N- (isoxazolyl) furan-sulfonamide and N- (isoxazolyl) pyrrolyl sulfonamides, and use of these sulfonamide the method of endothelin to the endothelin receptor by contacting endothelin receptor inhibition. By endothelin also provides a method of regulating disease treatment, which is administered inhibit or increase an endothelin effective amount of one or more active of these sulfonamides or prodrugs thereof.