Kinetic resolution of 3-hydroxycyclohexanone using different lipases

Abstract A new approach to enantiomerically enriched cyclic β-hydroxy ketones was developed. 3-Hydroxycyclohexanone was successfully resolved using lipase catalyzed transesterification. Among the lipases screened PFL, PCL, and PPL-II gave 57%, 39%, and 25% yield of the ( R )-3-oxocyclohexyl acetate with 52%, 75%, and 91% ee. The PPL-II gave the highest E -value (32). The absolute configuration of the product was determined by comparison with the literature data.